Among women of reproductive age, one of the most prevalent hormonal disorders is PCOS, or ovarian insufficiency. This condition may reach menopausal age as well, while the symptoms can change over time. The impact of PCOS is not only on ovarian function; it may lead to a number of serious health issues, such as infertility, type 2 diabetes, cardiovascular diseases, and even mental problems. The exact cause of PCOS is not known, with studies hinting at combined biological and environmental factors as its cause. Herein, we shall look at possible causes and major risk factors of the disorder.
Biological Factors in the Development of PCOS
- Genetic Factors
- Genetics: It has been unraveled that PCOS can actually run in the families. If the history is taken from a first-degree relative, say mother or sister, then you are likely at risk.
- Hormone production genes: Changes in genes that control the production of hormones can also be one of the causes of PCOS. Variants in the genes responsible for the production of androgens, such as testosterone, for example, result in high levels of these hormones and may cause PCOS.
- Metabolic disorders: Genetic variants that predispose to metabolic disorders in the pathway of glucose and lipid metabolism may lead to insulin resistance hence to PCOS.
- Insulin Resistance
In PCOS, the major factor contributing is insulin resistance, where cells in the human body do not respond to the hormone insulin. This is the hormone responsible for controlling blood sugar. Once this resistance is shown, an impulse sends out signals to produce more insulin in the body.
- Hormonal Influence: Such a high level of insulin, in turn, acts on the ovaries and can stimulate them into overproducing androgens or male hormones, symptoms of which can be as varying as acne, excessive hair growth, and menstrual problems.
- Ovarian Effects: Insulin resistance may, in turn, disrupt the normal menstrual cycle, which can lead the ovaries to develop small cysts; this generally occurs in women with PCOS, further reducing fertility.
- Hormonal Imbalance
A hormonal imbalance is responsible for a number of manifestations that clinically describe PCOS:
- Androgens: Most women with PCOS have high levels of androgens manifested by symptoms of excessive hairiness, acne, and even male-pattern baldness.
- Estrogen and Progesterone: The ratio between estrogen and progesterone in PCOS is sometimes disrupted. Consequently, it may cause infrequent or no menstrual flow, hence reducing fertility.
- LH and FSH: One of the common features in women with PCOS is an abnormal ratio of LH to FSH, which may result in defective ovulation and subsequently ovarian cyst formation.
Environmental Factors in the Development of PCOS
These environmental factors can be contributory in the development and advancement of PCOS while influencing symptoms through action on hormonal and metabolic systems.
- Dietary Influence
- High Sugar Intake: High intake of simple sugars may give a sudden rise in the level of blood sugar, leading after constant repetition to a greater production of insulin, and thereby, possibly, to insulin resistance.
- Refined Carbohydrates: White bread, white rice, pasta-the consumption of these types of food increases blood sugar and makes one prone to insulin resistance.
- Trans Fats: These are other kinds of fats present in processed foods, fast foods, cakes, and pastries. They do cause inflammation in the body and promote insulin resistance and hence may be very dangerous in worsening PCOS.
- Saturated Fats: Excessive intake of saturated fat derived from fatty meats, full-cream dairy products, and some vegetable oils heighten the level of cholesterol and androgens, leading to hormonal imbalance.
- Low Fiber Intake: Nutritional deficiency of dietary fiber can result in higher blood sugar and insulin. It helps in maintaining blood sugar levels and, in some cases, improves insulin sensitivity.
- High Dairy Products: In some studies, high products of dairy are associated with increased androgen among women with PCOS, similarly insulin from dairies causes insulin resistance.
- Processed Foods and Fast Food: These are typically riddled with sugars, toxic fat, and additives that inflame the body, lead to insulin resistance, and cause hormonal imbalance, which can worsen the chances of getting PCOS or exacerbate its symptoms.
- Excessive Caffeine: Some studies prove that too much caffeine has an adverse impact on the hormonal system balance, especially in women who suffer from PCOS, as it disrupts the levels of androgen and estrogen.
- Inadequate Levels of Nutrients: Vitamin D, B vitamins, omega-3 fatty acids, and magnesium are some nutrients that can prevent the hormones from carrying out their functions well and worsening the symptoms that come with PCOS.
- Environmental Pollution
- Hormone-disrupting chemicals: Some environmental chemicals, such as BPA and phthalates in plastics, personal care products, among others, interfere with normal body hormonal processes; thus, they alter the balance of sex hormones and increase symptoms of PCOS.
- Air pollution: Air pollution does this too, which has been directly linked with increased inflammation and insulin resistance-two very critical factors in the development of PCOS.
- Stress and Lifestyle
- Chronic Stress: Long-term stress increases the levels of cortisol. This heightens insulin resistance, hence causing hormonal imbalance. This can also affect menstrual cycles and increase symptoms of PCOS.
- Sedentary Lifestyle: Inactivity or lack of regular exercise leads to weight gain and the development of insulin resistance and metabolic disorders that increase vulnerability to PCOS.
- Weight and Obesity
The factors most closely related to environmental factors are obesity. Being overweight may enhance insulin resistance and hormonal imbalance. Having excess fat, especially within the abdominal part of the body, can enhance the production of androgens that may exacerbate symptoms in PCOS. Generally, women with PCOS have higher body mass indexes, and for such cases, obesity may further worsen this syndrome.
- Medications and Chemicals
Other medications and chemicals disturb the balance of hormones and can aggravate symptoms of PCOS. For instance, certain steroid drugs may affect the ovaries or other drugs and products that contain any form of hormone.
- Smoking
- Increased Androgens: Smokers have higher levels of androgen, which means more symptoms like hirsutism, acne, and scalp hair thinning.
- Decreased estrogen: Smokers, particularly cigarette smokers, contribute to the deteriorating levels of estrogen in the body. Lower levels of estrogen cause hormonal imbalance and increase the intensity of PCOS symptoms.
- Ovulation disorder: It interferes with ovulation and sometimes even stops the process completely, which is very hazardous in the case of women with PCOS.
- Damage to the eggs: The quality of the eggs deteriorates owing to the chemical action of tobacco products on the eggs, reducing the possibilities of successful fertilization.
Final Thoughts
This implies that PCOS, as a genetically based disease process, environmental factors interact with genes and can thus increase the chance of development or exacerbation of the syndrome. In saying this, negative environmental factors can make a profound influence on genetic susceptibility to PCOS. All these factors may be modified by lifestyle, healthy diet, stress reduction, and avoidance of harmful chemicals to prevent or mitigate symptoms of PCOS. Nutritional coaching is one of the most effective ways of treatment for the symptoms developed by PCOS. The best nutrition and gynaecology experts in Dr. Jam’s clinic are always ready to take your side during health improvement.
References
- https://pubmed.ncbi.nlm.nih.gov/29083730/#:~:text=Polycystic%20ovarian%20syndrome%20(PCOS)%20is,on%20the%20diagnostic%20criteria%20applied.
- https://www.medscape.com/viewarticle/551015_1.#:~:text=Polycystic%20ovary%20syndrome%20(PCOS)%20is,that%20cross%20the%20life%20span.
- https://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndrome#:~:text=Polycystic%20ovary%20syndrome%20(PCOS)%20is,and%20cysts%20in%20the%20ovaries.